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Induction of this biosynthetic pathway enhances intracellular GSH levels and promotes cancer cell resistance to ferroptosis, 142,143 whereas pharmacological inhibition of GSH synthesis by L-buthionine-(S,R)-sulfoximine (BSO), a GCL inhibitor, induces ferroptosis 144

Cryotherapy presents fewer concerns about long-term use

What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

The human hepatocyte growth factor receptor gene: complete structural organization and promoter characterization